Can multiple mosaics be combined to improve total integration time - and best method

I first became interested in mosaics after imaging portions of the Cygnus SNR separately, namely the Eastern and Western Veils.  I decided to try to capture them and the area between them in a 2x2 mosaic that included Pickerings Triangle in 2022.  This was also when I first discovered and tested out APP.  I was able to capture 50 minutes on each panel and got a respectable (although not really good) result combining the panels with APP and post-processing with Star Tools.

I considered going after more data the following year, but expanded my scope to a 2x4 panel mosaic that also attempts to capture some of the fainter details North of the area I got in 2022.  During three sessions over last year and this, I was able to get about 50 minutes worth of time on these 8 panels and produced a similar result as to where I have gotten with the 2x2 data from 2022.  I find it difficult to collect large amounts of time on target as there a very few good nights available to me and spreading that time over 8 panels is challenging.

In the last week or so I have been wondering whether I can use the overlapping data I collected in 2022 by combining the 2x2 and 2x4 integrated mosaics into a new mosaic.  If this is a reasonable thing to do I could concentrate on collecting data on just the northern 4 panels to quickly get to about 2 hours of time per panel and see if that improve my end result.  This is a screenshot of what the combined 2x2 and 2x4 mosaics looks like:

I have outlined the original 2x2 data to try and make this clearer.  I will process the combined data in StarTools and see whether the overlapping portions look better.

If this is a reasonable approach I am wondering (and will do further tests) whether I should use then 2x2 and 2x4 mosaics as my source, or if I get a better result by doing a single mosaic of all twelve individual panels into an end result.  I did take one pass at this option, but the result was rather bland color-wise as I had used LNC when integrating the individual panels of the 2x4 data.  I have since reintegrated each ot the panels with no LNC and the result is more vibrant.  That is the overlapped mosaic I am running through StarTools right now.

Any thoughts, questions or comments are appreciated.

Bob