OSC processing order: RGBHOO

Hi.  Wondering: if I have RBG and HaOIII data from my OSC camers (ASI294MC), is there a difference in the end product between these two processing orders (effectively, separating channels early or late):

1) easier processing, late separation:

- Process RGB all the way through integration

- Process HaOIII with "HaOIII color" algorithm, all the way through integration

- Do some minor cleanup, like early cropping, remove light pollution, and maybe calibrate star colors (for RGB only)

- Normalize the two stacked images

- In "Combine RGB tool" with RGBHOO formula, load RGB stack into R, G, B channels and load HaOIII stack into Ha, OIII, OIII channels

OR

2) early separation:

- Process RGB through Calibration, split R, G, and B and process those separately through Integration

- Process "HaOIII, extract Ha" through integration, then "HaOIII, extract OIII" through integration

- Do some minor cleanup, like early cropping and remove light pollution for each stack

- Nornmalize all five stacks 

- In "Combine RGB tool" with RGBHOO formula, load R, G, B into their channels separately and then Ha, OIII separately

(Same question for HSO or similar processing)

In effect, does it make a difference at what point in the process I separate the individual channels out of the color image (and if so, why?)

TIA!

H